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The Science of Diabetes
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Insulin The insulin molecule is a relatively small polypeptide made up of 51 amino acids. It consists of two chains which are connected by disulfide links. Most polypeptides start out as larger molecules and gradually decrease in size as they work their way out of the cell. The gene for the insulin molecule is lies on chromosome 11. Insulin was first isolated by Dr. Fred Banting and Charles Best in 1921. The story of the discovery of insulin is told elsewhere on this site. Following the discovery of insulin, the production of insulin for clinical use was taken up by the Eli Lilly Company in Indianapolis, Indiana and the Novo Company in Europe/Denmark. Scientific interest in insulin and the beta cell continued. In 195 , the structure of insulin was established by Dr. Fred Sanger.
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